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Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms
Developmental Cell ( IF 11.8 ) Pub Date : 2024-02-14 , DOI: 10.1016/j.devcel.2024.01.023
Matthew J. Shannon , Gina L. McNeill , Burak Koksal , Jennet Baltayeva , Jasmin Wächter , Barbara Castellana , Maria S. Peñaherrera , Wendy P. Robinson , Peter C.K. Leung , Alexander G. Beristain

Although the merits of trophoblast organoids have been established, a high-resolution assessment of these systems has not been performed. Here, Shannon et al. generate a single-cell transcriptomic atlas of two distinct trophoblast organoid systems that defines their similarities and discrepancies with reference to trophoblasts.

中文翻译:

作为胎盘建模平台的原代和干细胞衍生的人类滋养层类器官的单细胞评估

尽管滋养层类器官的优点已经确定,但尚未对这些系统进行高分辨率评估。在这里,香农等人。生成两个不同滋养层类器官系统的单细胞转录组图谱,定义它们与滋养层的相似性和差异。
更新日期:2024-02-14
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