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Construction of single-cell cross-species chromatin accessibility landscapes with combinatorial-hybridization-based ATAC-seq
Developmental Cell ( IF 11.8 ) Pub Date : 2024-02-07 , DOI: 10.1016/j.devcel.2024.01.015
Guodong Zhang , Yuting Fu , Lei Yang , Fang Ye , Peijing Zhang , Shuang Zhang , Lifeng Ma , Jiaqi Li , Hanyu Wu , Xiaoping Han , Jingjing Wang , Guoji Guo

Zhang et al. develop combinatorial-hybridization-based ATAC-seq (CH-ATAC-seq) to construct chromatin accessibility landscapes of zebrafish, , and . By comparing cell-type-specific cCREs and genes across vertebrates and invertebrates, conserved regulatory programs are identified, providing a valuable resource for future cross-species analysis.

中文翻译:

使用基于组合杂交的 ATAC-seq 构建单细胞跨物种染色质可及性景观

张等人。开发基于组合杂交的 ATAC-seq (CH-ATAC-seq) 来构建斑马鱼的染色质可及性景观, 和 。通过比较脊椎动物和无脊椎动物的细胞类型特异性 cCRE 和基因,可以识别保守的调控程序,为未来的跨物种分析提供宝贵的资源。
更新日期:2024-02-07
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