Due to their immunomodulatory capacities, mesenchymal stem cells (MSCs) have been extensively used as therapeutic approaches in cell-based therapy for various inflammatory diseases. Several lines of studies have shown that the most beneficial effects of MSCs are associated with MSC-derived exosomes. Exosomes are nanoscale extracellular vesicles that contain important biomolecules such as RNA, microRNAs (miRNAs), DNA, growth factors, enzymes, chemokines, and cytokines that regulate immune cell functions and parenchymal cell survival. Recently, exosomes, especially MSC-derived exosomes, have been shown to have protective effects in allergic airway inflammation. This review focused on the immune-regulatory potential of MSC-derived exosomes as nanoscale delivery systems in the treatment of allergic airway inflammation.

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间充质干细胞来源的外泌体对过敏性气道炎症的治疗潜力

由于其免疫调节能力，间充质干细胞（MSC）已被广泛用作各种炎症性疾病的细胞治疗方法。多项研究表明，间充质干细胞最有益的作用与间充质干细胞衍生的外泌体有关。外泌体是纳米级的细胞外囊泡，含有重要的生物分子，如 RNA、microRNA (miRNA)、DNA、生长因子、酶、趋化因子和调节免疫细胞功能和实质细胞存活的细胞因子。最近，外泌体，特别是间充质干细胞衍生的外泌体，已被证明对过敏性气道炎症具有保护作用。本综述重点关注 MSC 衍生的外泌体作为纳米级递送系统在治疗过敏性气道炎症中的免疫调节潜力。