Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome,Cell Host & Microbe

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Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome
Cell Host & Microbe ( IF 30.3 ) Pub Date : 2024-02-16 , DOI: 10.1016/j.chom.2024.01.013
Qiyi Chen , Chunyan Wu , Jinfeng Xu , Chen Ye , Xiang Chen , Hongliang Tian , Naixin Zong , Shaoyi Zhang , Long Li , Yuan Gao , Di Zhao , Xiaoqiong Lv , Qilin Yang , Le Wang , Jiaqu Cui , Zhiliang Lin , Jubao Lu , Rong Yang , Fang Yin , Nan Qin , Ning Li , Qian Xu , Huanlong Qin

Studies on fecal microbiota transplantation (FMT) have reported inconsistent connections between clinical outcomes and donor strain engraftment. Analyses of subspecies-level crosstalk and its influences on lineage transfer in metagenomic FMT datasets have proved challenging, as single-nucleotide polymorphisms (SNPs) are generally not linked and are often absent. Here, we utilized species genome bin (SGB), which employs co-abundance binning, to investigate subspecies-level microbiome dynamics in patients with autism spectrum disorder (ASD) who had gastrointestinal comorbidities and underwent encapsulated FMT (Chinese Clinical Trial: 2100043906). We found that interactions between donor and recipient microbes, which were overwhelmingly phylogenetically divergent, were important for subspecies transfer and positive clinical outcomes. Additionally, a donor-recipient SGB match was indicative of a high likelihood of strain transfer. Importantly, these ecodynamics were shared across FMT datasets encompassing multiple diseases. Collectively, these findings provide detailed insight into specific microbial interactions and dynamics that determine FMT success.

更新日期：2024-02-16

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