Combination of different therapies is an attractive approach for cancer therapy. However, it is a challenge to synchronize different therapies for maximization of therapeutic effects. In this work, a smart composite scaffold that could synchronize magnetic hyperthermia and chemotherapy was prepared by hybridization of magnetic FeO nanoparticles and doxorubicin (Dox)-loaded thermosensitive liposomes with biodegradable polymers. Irradiation of alternating magnetic field (AMF) could not only increase the scaffold temperature for magnetic hyperthermia but also trigger the release of Dox for chemotherapy. The two functions of magnetic hyperthermia and chemotherapy were synchronized by switching AMF on and off. The synergistic anticancer effects of the composite scaffold were confirmed by cell culture and animal experiments. The composite scaffold could efficiently eliminate breast cancer cells under AMF irradiation. Moreover, the scaffold could support proliferation and adipogenic differentiation of mesenchymal stem cells for adipose tissue reconstruction after anticancer treatment. regeneration experiments showed that the composite scaffolds could effectively maintain their structural integrity and facilitate the infiltration and proliferation of normal cells within the scaffolds. The composite scaffold possesses multi-functions and is attractive as a novel platform for efficient breast cancer therapy.

中文翻译：

---

智能复合支架同步磁热疗和化疗以实现有效的乳腺癌治疗

不同疗法的组合是癌症治疗的一种有吸引力的方法。然而，同步不同的疗法以最大化治疗效果是一个挑战。在这项工作中，通过磁性 Fe3O 纳米颗粒和负载阿霉素（Dox）的热敏脂质体与可生物降解聚合物的杂交，制备了一种可以同步磁热疗和化疗的智能复合支架。交变磁场（AMF）照射不仅可以提高磁热疗的支架温度，还可以触发Dox的释放用于化疗。通过AMF的开启和关闭来同步磁热疗和化疗两种功能。细胞培养和动物实验证实了复合支架的协同抗癌作用。该复合支架在AMF照射下可以有效消除乳腺癌细胞。此外，该支架可以支持间充质干细胞的增殖和成脂分化，用于抗癌治疗后的脂肪组织重建。再生实验表明，复合支架能够有效保持其结构完整性，并促进支架内正常细胞的浸润和增殖。该复合支架具有多功能，作为有效乳腺癌治疗的新平台具有吸引力。