Weak, but environmentally relevant concentrations of contaminants can have subtle, yet important, impacts on organisms, which are often overlooked due to the lack of acute impacts and the timing of exposure. Thus, recognizing simple, non-invasive markers of contamination events is essential for early detection and addressing the effects of exposure to weak environmental contaminants. Here, we tested whether exposure to an environmentally relevant concentration of Bisphenol-A (BPA), a common and persistent contaminant in aquatic systems, affects the lateralization of adult zebrafish (), a widely used model organism in ecotoxicology. We found that 73.5% of adult zebrafish displayed a left-side bias when they approached a visual cue, but that those exposed to weak BPA (0.02 mg/L) for 7 days did not exhibit laterality. Only 47.1% displayed a left-side bias. We found no differences in activity level and visual sensitivity, motor and sensory mechanisms, that regulate lateralized responses and that were unaffected by weak BPA exposure. These findings indicate the reliability of laterality as a simple measure of contaminant exposure and for future studies of the detailed mechanisms underlying subtle and complex behavioral effects to pollutants.

中文翻译：

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暴露于环境相关浓度的双酚 A 与成年斑马鱼（斑马鱼）视觉偏侧化丧失有关

较弱但与环境相关的污染物浓度可能会对生物体产生微妙但重要的影响，但由于缺乏严重影响和暴露时间，这种影响常常被忽视。因此，识别污染事件的简单、非侵入性标记对于早期检测和解决暴露于弱环境污染物的影响至关重要。在这里，我们测试了暴露于环境相关浓度的双酚 A (BPA)（水生系统中常见且持久的污染物）是否会影响成年斑马鱼（生态毒理学中广泛使用的模式生物）的侧化。我们发现，73.5% 的成年斑马鱼在接近视觉提示时表现出左侧偏向，但那些暴露于弱 BPA (0.02 mg/L) 7 天的斑马鱼并没有表现出偏侧性。只有 47.1% 的人表现出左侧偏见。我们发现活动水平和视觉敏感性、运动和感觉机制没有差异，这些机制调节侧化反应，并且不受弱 BPA 暴露的影响。这些发现表明，侧向性作为污染物暴露的简单测量方法是可靠的，并且可用于未来研究污染物微妙而复杂的行为影响背后的详细机制。