The potential for oil spills poses a threat to marine organisms, the toxicity of which has been attributed primarily to polycyclic aromatic compounds (PACs). Predictive tools such as the target lipid model (TLM) have been developed to forecast and assess these risks. The aim of the present study was to characterize the cardiotoxicity of 10 structurally diverse PACs in American lobster (Homarus americanus) larvae by assessing heart rate following a 48 h exposure in a passive dosing system, and subsequently use the TLM framework to calculate a critical target lipid body burden (CTLBB) for bradycardia. Exposure to 8 of the 10 PACs resulted in concentration-dependent bradycardia, with phenanthrene causing the greatest effect. The TLM was able to effectively characterize bradycardia in American lobsters, and the cardiotoxic CTLBB value determined in this study is among the most sensitive endpoints included in the CTLBB database. This study is one of the first to apply the TLM to a cardiac endpoint and will improve predictive models for assessing sublethal impacts of oil spills on American lobster populations.

中文翻译：

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接触单个多环芳香族化合物会损害美洲龙虾（Homarus americanus）幼虫的心脏功能

石油泄漏的可能性对海洋生物构成威胁，其毒性主要归因于多环芳香族化合物（PAC）。目标脂质模型 (TLM) 等预测工具已被开发来预测和评估这些风险。本研究的目的是通过评估在被动给药系统中暴露 48 小时后的心率来表征 10 种结构不同的 PAC 对美洲龙虾 (Homarus americanus) 幼虫的心脏毒性，然后使用 TLM 框架计算关键目标心动过缓的脂质体负荷（CTLBB）。接触 10 种 PAC 中的 8 种会导致浓度依赖性心动过缓，其中菲造成的影响最大。TLM 能够有效地表征美洲龙虾的心动过缓，并且本研究中确定的心脏毒性 CTLBB 值是 CTLBB 数据库中包含的最敏感的终点之一。这项研究是将 TLM 应用于心脏终点的首批研究之一，并将改进用于评估漏油对美国龙虾种群亚致死影响的预测模型。