Human norovirus infection is a major global health concern, but a suitable animal model is lacking. We have established repeated infection with human norovirus in rhesus macaques via oral challenge. Animals demonstrate virus shedding in the stool and subsequent serum antibody responses, and virus replication is detected in the small intestine.

中文翻译：

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人类诺如病毒感染的恒河猴模型

人类诺如病毒感染是全球主要的健康问题，但缺乏合适的动物模型。我们已经通过口服攻击在恒河猴中建立了人类诺如病毒的重复感染。动物表现出病毒在粪便中脱落和随后的血清抗体反应，并且在小肠中检测到病毒复制。