Objective

There is widespread overuse of antibiotics in neonatal intensive care units (NICUs). The objective of this study was to safely reduce antibiotic use in participating NICUs by targeting early-onset sepsis (EOS) management.

Study design

Twenty-eight NICUs participated in this statewide multicenter antibiotic stewardship quality improvement collaborative. The primary aim was to reduce the total monthly mean antibiotic utilization rate (AUR) by 25% in participant NICUs.

Result

Aggregate AUR was reduced by 15.3% (p < 0.001). There was a wide range in improvement among participant NICUs. There were no increases in EOS rates or nosocomial infection rates related to the intervention.

Conclusion

Participation in this multicenter NICU antibiotic stewardship collaborative targeting EOS was associated with an aggregate reduction in antibiotic use. This study informs efforts aimed at sustaining improvements in NICU AURs.

中文翻译：

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28 个 NICU 参与针对早发败血症抗生素使用的质量改进合作

客观的

新生儿重症监护病房 (NICU) 普遍存在抗生素过度使用的情况。本研究的目的是通过针对早发败血症 (EOS) 的管理，安全地减少参与 NICU 的抗生素使用。

学习规划

二十八个新生儿重症监护室参与了这项全州多中心抗生素管理质量改进合作。主要目标是将参与 NICU 的每月平均抗生素使用率 (AUR) 降低 25%。

结果

总 AUR 降低了 15.3% ( p  < 0.001)。参与 NICU 的患者的病情都有很大改善。与干预相关的 EOS 率或医院感染率没有增加。

结论

参与这项针对 EOS 的多中心 NICU 抗生素管理协作与抗生素使用的总体减少有关。这项研究为旨在持续改善 NICU AUR 的努力提供了信息。