A statewide genomic surveillance system for invasive Group A Streptococcus was implemented in Arizona in June 2019, resulting in 1,046 isolates being submitted for genomic analysis to characterize emm-types and identify transmission clusters. Eleven of the 32 identified distinct emm-types comprised >80% of samples, with 29.7% of all isolates being typed as emm49 (and its genetic derivative emm151). Phylogenetic analysis initially identified an emm49 genomic cluster of four isolates that rapidly expanded over subsequent months (June 2019-February 2020). Public health investigations identified epidemiologic links with three different long-term care facilities, resulting in specific interventions. Unbiased genomic surveillance allowed for identification and response to clusters that would have otherwise remained undetected.

中文翻译：

---

2019-2021 年，通过全州基因组监测系统在亚利桑那州医疗机构内部和跨医疗机构中发现的大群侵袭性 emm49 A 链球菌

亚利桑那州于 2019 年 6 月实施了全州范围内的侵袭性 A 组链球菌基因组监测系统，提交了 1,046 个分离株进行基因组分析，以表征 emm 类型并识别传播簇。32 个已鉴定的不同 emm 类型中的 11 个占样本的 80% 以上，其中所有分离株中 29.7% 的类型为 emm49（及其遗传衍生物 emm151）。系统发育分析最初确定了由四个分离株组成的 emm49 基因组簇，该簇在接下来的几个月（2019 年 6 月至 2020 年 2 月）中迅速扩展。公共卫生调查确定了与三个不同长期护理机构的流行病学联系，从而采取了具体的干预措施。无偏见的基因组监测可以识别和响应原本不会被发现的簇。