Assessing the difference in contamination of retail meat with multidrug-resistant bacteria using for-consumer package label claims that indicate on-farm antibiotic use practices— United States, 2016–2019,Journal of Exposure Science and Environmental Epidemiology

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Assessing the difference in contamination of retail meat with multidrug-resistant bacteria using for-consumer package label claims that indicate on-farm antibiotic use practices— United States, 2016–2019
Journal of Exposure Science and Environmental Epidemiology ( IF 4.1 ) Pub Date : 2024-02-19 , DOI: 10.1038/s41370-024-00649-y
G Sean Stapleton _{1,

2} , Gabriel K Innes ₃ , Keeve E Nachman _{1,

2,

4} , Joan A Casey ₅ , Andrew N Patton ₆ , Lance B Price ₇ , Sara Y Tartof _{8,

9} , Meghan F Davis _{1,

10}

Affiliation

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Center for Livable Future, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Yuma Center for Excellence in Desert Agriculture, Yuma, AZ, USA.
Risk Sciences and Public Policy Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA, USA.
Geospatial Analysis Lab, University of San Francisco, Harney Science Center, San Francisco, CA, USA.
Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA.
Department of Molecular and Comparative Pathobiology & Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Background

Antibiotic use in food-producing animals can select for antibiotic resistance in bacteria that can be transmitted to people through contamination of food products during meat processing. Contamination resulting in foodborne illness contributes to adverse health outcomes. Some livestock producers have implemented antibiotic use reduction strategies marketed to consumers on regulated retail meat packaging labels (“label claims”).

Objective

We investigated whether retail meat label claims were associated with isolation of multidrug-resistant organisms (MDROs, resistant to ≥3 classes of antibiotics) from U.S. meat samples.

Methods

We utilized retail meat data from the U.S. Food and Drug Administration National Antimicrobial Resistance Monitoring System (NARMS) collected during 2016–2019 for bacterial contamination of chicken breast, ground turkey, ground beef, and pork chops. We used modified Poisson regression models to compare the prevalence of MDRO contamination among meat samples with any antibiotic restriction label claims versus those without such claims (i.e., conventionally produced).

Results

In NARMS, 62,338 meat samples were evaluated for bacterial growth from 2016–2019. Of these, 24,446 (39%) samples had label claims that indicated antibiotic use was restricted during animal production. MDROs were isolated from 2252 (4%) meat samples, of which 71% (n = 1591) were conventionally produced, and 29% (n = 661) had antibiotic restriction label claims. Compared with conventional samples, meat with antibiotic restriction label claims had a statistically lower prevalence of MDROs (adjusted prevalence ratio: 0.66; 95% CI: 0.61, 0.73). This relationship was consistent for the outcome of any bacterial growth.

Impact

This repeated cross-sectional analysis of a nationally representative retail meat surveillance database in the United States supports that retail meats labeled with antibiotic restriction claims were less likely to be contaminated with MDROs compared with retail meat without such claims during 2016–2019.
These findings indicate the potential for the public to become exposed to bacterial pathogens via retail meat and emphasizes a possibility that consumers could reduce their exposure to environmental reservoirs of foodborne pathogens that are resistant to antibiotics.

中文翻译：

使用表明农场抗生素使用实践的消费者包装标签声明来评估零售肉类受多重耐药细菌污染的差异——美国，2016-2019

背景

食用动物使用抗生素可能会导致细菌产生抗生素耐药性，这些细菌可以通过肉类加工过程中食品污染传播给人类。导致食源性疾病的污染会导致不良的健康结果。一些畜牧生产商实施了抗生素使用减少策略，在受监管的零售肉类包装标签（“标签声明”）上向消费者推销。

客观的

我们调查了零售肉类标签声明是否与从美国肉类样品中分离出多重耐药微生物（MDRO，对 ≥ 3 类抗生素具有耐药性）有关。

方法

我们利用美国食品和药物管理局国家抗菌素耐药性监测系统 (NARMS) 在 2016 年至 2019 年期间收集的零售肉类数据，了解鸡胸肉、碎火鸡、碎牛肉和猪排的细菌污染情况。我们使用改进的泊松回归模型来比较带有任何抗生素限制标签声明的肉类样品与没有此类声明（即传统生产的）的肉类样品中MDRO污染的流行率。

结果

NARMS 对 2016 年至 2019 年 62,338 个肉类样本的细菌生长情况进行了评估。其中，24,446 个（39%）样本的标签声明表明在动物生产过程中限制使用抗生素。从 2252 个（4%）肉类样品中分离出多重耐药菌，其中 71%（ n = 1591）是传统生产的，29%（ n = 661）有抗生素限制标签声明。与传统样品相比，具有抗生素限制标签声明的肉类的多重耐药菌患病率在统计学上较低（调整后患病率：0.66；95% CI：0.61，0.73）。这种关系对于任何细菌生长的结果都是一致的。

影响

对美国具有全国代表性的零售肉类监测数据库进行的重复横断面分析表明，2016 年至 2019 年期间，与没有此类声明的零售肉类相比，带有抗生素限制声明的零售肉类受到 MDRO 污染的可能性较小。
这些发现表明公众有可能通过零售肉类接触细菌病原体，并强调消费者可以减少接触对抗生素具有抗药性的食源性病原体环境库的可能性。

更新日期：2024-02-19

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