Levodopa Impairs the Energy Metabolism of the Basal Ganglia In Vivo,Annals of Neurology

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Levodopa Impairs the Energy Metabolism of the Basal Ganglia In Vivo
Annals of Neurology ( IF 11.2 ) Pub Date : 2024-02-17 , DOI: 10.1002/ana.26884
Jannik Prasuhn _{1,

2,

3,

4,

5} , Tanja Schiefen _{1,

3} , Theresia Güber _{1,

3} , Julia Henkel _{1,

2,

3} , Jan Uter _{1,

2,

3} , Julia Steinhardt _{1,

3} , Britta Wilms _{3,

6,

7} , Norbert Brüggemann _{1,

2,

3}

Affiliation

One proposed mechanism of disease progression in Parkinson's disease includes the interplay of endogenous dopamine toxicity and mitochondrial dysfunction. However, the in-vivo effects of exogenous dopamine administration on cerebral bioenergetics are unknown.

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