Owing to their superior hydrophilicity, zwitterionic molecules are known to form a strong hydration layer serving as an effective antifouling barrier. Despite their widespread use, the immobilization of zwitterionic molecules on various surfaces has posed a considerable challenge. Herein, we designed zwitterionic polyethers functionalized with mussel-inspired catechol moieties, which can be applied as versatile coatings with enhanced antifouling properties for biomedical surfaces. A series of block polyethers were synthesized via sequential anionic ring-opening polymerization of catechol-acetonide glycidyl ether and N,N-diisopropyl ethanolamine glycidyl ether, followed by post-polymerization modification to afford the desired zwitterionic brushes. The versatile surface adsorption and superior antifouling effects of the synthesized polyether brushes were evaluated using atomic force microscopy, quartz crystal microbalance with dissipation, and bioassay on the biomedical device surfaces. This study highlights the superior antifouling properties of zwitterionic polyether brushes, with potential applications in biomedical surfaces.

中文翻译：

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用于防污生物医学表面的受贻贝启发的两性离子共聚醚

由于其优异的亲水性，两性离子分子可以形成强大的水化层，作为有效的防污屏障。尽管用途广泛，但将两性离子分子固定在各种表面上仍提出了相当大的挑战。在这里，我们设计了用受贻贝启发的儿茶酚部分功能化的两性离子聚醚，它可以用作多功能涂料，具有增强的生物医学表面防污性能。通过儿茶酚丙酮缩水甘油醚和N , N-二异丙基乙醇胺缩水甘油醚的连续阴离子开环聚合合成了一系列嵌段聚醚，然后进行聚合后改性以得到所需的两性离子刷。使用原子力显微镜、耗散石英晶体微天平以及生物医学设备表面的生物测定来评估合成聚醚刷的多功能表面吸附和优异的防污效果。这项研究强调了两性离子聚醚刷的卓越防污性能，在生物医学表面具有潜在的应用前景。