The fast clearance and limited tumor accumulation seriously imperil practical applications of nano delivery systems (NDSs). Therefore, the additional engineering modification is usually needed. An NDS integrating flexible camouflage, specific bio-recognition, and sensitive stimuli-responsiveness into one sequence would be “smart” and highly effective. Hence, we systematically summarize the related principles, methods, and progress; meanwhile, provide instructive prospection.

中文翻译：

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肿瘤特异性治疗的纳米工程策略

快速清除和有限的肿瘤积累严重危及纳米递送系统（NDS）的实际应用。因此，通常需要进行额外的工程修改。一种将灵活伪装、特定生物识别和敏感刺激响应能力集成到一个序列中的 NDS 将是“智能”且高效的。为此，我们系统总结了相关原理、方法和进展；同时，提供指导性展望。