Demonstrated is the successful implementation of a novel route for the preparation of heterofunctional diblock copolymers derived from 2-vinyl-4,4-dimethyl azlactone (VDM) by sequential reversible addition–fragmentation chain transfer (RAFT) polymerization and post-polymerization modification (PPM). The relevance of the sequence is demonstrated using as starting material a copolymer of VDM and N,N-dimethylacrylamide (DMA) prepared by redox-initiated RAFT polymerization at room temperature. By using an equimolar ratio of amine to azlactone groups during the first PPM, the thiocarbonylthio chain end survives the click aminolysis and the resulting copolymer can then be extended with a second block containing VDM. Subsequent PPM with a second amine yields a diblock copolymer with a unique VDM-derived backbone in both blocks, which differ only in the nature of the side chains.

中文翻译：

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一石二鸟：从一种二氢唑酮官能化单体到异官能二嵌段共聚物

展示了一种通过顺序可逆加成-断裂链转移（RAFT）聚合和聚合后改性（PPM）成功制备由 2-乙烯基-4,4-二甲基吖内酯（VDM）衍生的异功能二嵌段共聚物的新路线）。使用在室温下通过氧化还原引发的 RAFT 聚合制备的VDM 和N , N-二甲基丙烯酰胺 (DMA)的共聚物作为起始材料，证明了该序列的相关性。通过在第一个 PPM 过程中使用等摩尔比的胺与二氢唑酮基团，硫代羰基硫链末端在点击氨解作用中幸存下来，然后所得的共聚物可以用含有 VDM 的第二个嵌段进行延伸。随后使用第二种胺进行 PPM 生成二嵌段共聚物，其两个嵌段均具有独特的 VDM 衍生主链，其区别仅在于侧链的性质。