O-linked N-acetylglucosamine (O-GlcNAc) is an endogenous form of glycosylation that alters the structure of α-synuclein amyloid fibrils and attenuates their pathogenetic properties. The modified fibrils have a significantly reduced ability to seed the aggregation of endogenous α-synuclein in cultured neurons and in mice brains in vivo, which results in reduced pathology.

中文翻译：

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翻译后糖基化减少 α-突触核蛋白病理形成

O-连接的 N-乙酰氨基葡萄糖 (O-GlcNAc) 是一种内源性糖基化形式，可改变 α-突触核蛋白淀粉样原纤维的结构并减弱其致病特性。修饰后的原纤维显着降低了在培养的神经元和体内小鼠大脑中内源性α-突触核蛋白聚集的能力，从而减少了病理学。