Transporters and channels have strong potential as drug targets, but drug discovery targeting these membrane-embedded molecules is challenging. Fragment-based ligand discovery combined with chemical proteomics offers a promising solution to the search for inhibitors of solute transporter family members.

中文翻译：

---

击沉航母

转运蛋白和通道作为药物靶点具有强大的潜力，但针对这些膜嵌入分子的药物发现具有挑战性。基于片段的配体发现与化学蛋白质组学相结合，为寻找溶质转运蛋白家族成员的抑制剂提供了一种有前途的解决方案。