Microglia/macrophages line the border of demyelinated lesions in both cerebral white matter and the cortex in the brains of multiple sclerosis patients. Microglia/macrophages associated with chronic white matter lesions are thought to be responsible for slow lesion expansion and disability progression in progressive multiple sclerosis, whereas those lining gray matter lesions are less studied. Profiling these microglia/macrophages could help to focus therapies on genes or pathways specific to lesion expansion and disease progression.

中文翻译：

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多发性硬化症慢性活动性和软膜下灰质病变边界小胶质细胞/巨噬细胞的转录谱

在多发性硬化症患者的大脑白质和皮质中，小胶质细胞/巨噬细胞位于脱髓鞘病变的边界。与慢性白质病变相关的小胶质细胞/巨噬细胞被认为是进行性多发性硬化症中病变缓慢扩张和残疾进展的原因，而那些衬里灰质病变的研究较少。对这些小胶质细胞/巨噬细胞进行分析可以帮助将治疗集中在针对病变扩展和疾病进展的基因或途径上。