Insertable biosensor systems are medical diagnostic devices with two primary components: an implantable biosensor within the body and a wearable monitor that can remotely interrogate the biosensor from outside the body. Because the biosensor does not require a physical connection to the electronic monitor, insertable biosensor systems promise improved patient comfort, reduced inflammation and infection risk, and extended operational lifetimes relative to established percutaneous biosensor systems. However, the lack of physical connection also presents technical challenges that have necessitated new innovations in developing sensing chemistries, transduction methods, and communication modalities. In this review, we discuss the key developments that have made insertables a promising option for longitudinal biometric monitoring and highlight the essential needs and existing development challenges to realizing the next generation of insertables for extended-use diagnostic and prognostic devices.Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 26 is May 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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可插入生物传感器：将植入传感材料与可穿戴监视器相结合

可插入生物传感器系统是具有两个主要组件的医疗诊断设备：体内可植入生物传感器和可从体外远程询问生物传感器的可穿戴监视器。由于生物传感器不需要与电子监视器进行物理连接，因此与现有的经皮生物传感器系统相比，可插入生物传感器系统有望提高患者舒适度，降低炎症和感染风险，并延长使用寿命。然而，物理连接的缺乏也带来了技术挑战，需要在开发传感化学、转导方法和通信方式方面进行新的创新。在这篇综述中，我们讨论了使可插入物成为纵向生物识别监测有前途的选择的关键发展，并强调了实现下一代可插入物用于长期使用诊断和预后设备的基本需求和现有的开发挑战。预计最终在线发布日期《生物医学工程年度评论》第 26 卷的发布时间为 2024 年 5 月。请参阅 http://www.annualreviews.org/page/journal/pubdates 了解修订后的估计。