Abstract

This is a protocol for an overview to summarize the findings of Systematic Reviews (SR) dealing with Photodynamic Inactivation (PDI) for control of oral diseases. Specific variables of oral infectious will be considered as outcomes, according to dental specialty. Cochrane Database of Systematic Reviews (CDSR), MEDLINE, LILACS, Embase, and Epistemonikos will be searched, as well as reference lists. A search strategy was developed for each database using only terms related to the intervention (PDI) aiming to maximize sensitivity. After checking for duplicate entries, selection of reviews will be performed in a two-stage technique: two authors will independently screening titles and abstracts, and then full texts will be assessed for inclusion/exclusion criteria. Any disagreement will be resolved through discussion and/or consultation with a third reviewer. Data will be extracted following the recommendations in Chapter V of Cochrane Handbook and using an electronic pre-specified form. The evaluation of the methodological quality and risk of bias (RoB) of the SR included will be carried out using the AMSTAR 2 and ROBIS. Narrative summaries of relevant results from the individual SR will be carried out and displayed in tables and figures. A specific summary will focus on PDI parameters and study designs, such as the type and concentration of photosensitizer, pre-irradiation time, irradiation dosimetry, and infection or microbiological models, to identify the PDI protocols with clinical potential. We will summarize the quantitative results of the SRs narratively.

Graphical abstract

中文翻译：

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系统评价概述的协议，以绘制不同牙科专业的光动力失活证据

摘要

这是一个概述协议，总结了处理光动力失活（PDI）以控制口腔疾病的系统评价（SR）的发现。根据牙科专业，口腔感染的特定变量将被视为结果。将检索 Cochrane 系统评价数据库 (CDSR)、MEDLINE、LILACS、Embase 和 Epistemonikos 以及参考文献列表。仅使用与干预（PDI）相关的术语为每个数据库制定了搜索策略，旨在最大限度地提高敏感性。检查重复条目后，将以两阶段技术进行评论选择：两位作者将独立筛选标题和摘要，然后评估全文的纳入/排除标准。任何分歧将通过讨论和/或与第三位评审员协商解决。将按照《Cochrane 手册》第五章的建议并使用预先指定的电子表格提取数据。将使用 AMSTAR 2 和 ROBIS 对 SR 的方法学质量和偏倚风险 (RoB) 进行评估。将对各个 SR 的相关结果进行叙述性总结并以表格和图形的形式显示。具体总结将重点关注 PDI 参数和研究设计，例如光敏剂的类型和浓度、预照射时间、照射剂量测定以及感染或微生物模型，以确定具有临床潜力的 PDI 方案。我们将以叙述方式总结 SR 的定量结果。

图形概要