Due to the location and toxicity of treatments, head and neck cancer (HNC) has a major impact on quality of life (QoL). Objective to assess the effects of geriatric-assessment (GA)-driven interventions on QoL over 2 years in older adults with HNC. EGeSOR was a randomized study of HNC patients aged ≥65, receiving a pretreatment GA, a geriatric intervention and follow-up (intervention) or standard of care (control). The primary endpoint was QoL score (EORTC QLQ-C30, QLQ-HN35) over 24 months. 475 patients were included (median age: 75.3; women: 31%; oral cancer: 44%). QoL scores improved over 24 months with various trajectories, without significant differences between the groups. 74% of patients (interventional group) did not receive the complete intervention. Cancer characteristics, functional status, and risk of frailty were associated with change in the Global Health Status QoL score. There is a need to develop alternative model of implementation such as patient-centered healthcare pathways. Trial registration NCT02025062

中文翻译：

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老年头颈癌患者的老年评估和 2 年生活质量

由于治疗的部位和毒性，头颈癌 (HNC) 对生活质量 (QoL) 有重大影响。目的评估老年评估 (GA) 驱动的干预措施对患有 HNC 的老年人 2 年内生活质量的影响。 EGeSOR 是一项针对年龄≥65 岁的 HNC 患者的随机研究，这些患者接受治疗前 GA、老年干预和随访（干预）或标准护理（对照）。主要终点是 24 个月内的 QoL 评分（EORTC QLQ-C30、QLQ-HN35）。纳入 475 名患者（中位年龄：75.3 岁；女性：31%；口腔癌：44%）。 24 个月内，生活质量得分以不同的轨迹改善，但各组之间没有显着差异。 74%的患者（干预组）没有接受完整的干预。癌症特征、功能状态和虚弱风险与全球健康状况生活质量评分的变化相关。需要开发替代的实施模式，例如以患者为中心的医疗保健途径。试用注册NCT02025062