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Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors
ChemMedChem ( IF 3.4 ) Pub Date : 2024-02-07 , DOI: 10.1002/cmdc.202300680
Ismail Koyuncu 1 , Ebru Temiz 2 , Eray Metin Güler 3 , Mustafa Durgun 4 , Ozgür Yuksekdag 1 , Simone Giovannuzzi 5 , Claudiu T. Supuran 5
Affiliation  

2-bromo-N-(4-sulfamoylphenyl)propanamide (MMH-1) was synthesized. The inhibition property of the compound MMH-1 was examined on hCA I, II, IX, XII. The cytotoxic effect of MMH-1 on cancer and normal cells was tested and found to selectively affect MDA-MB-231 cells.

中文翻译:

新型磺酰胺作为碳酸酐酶 IX 抑制剂对抗侵袭性肿瘤的有效抗癌潜力

合成了2-溴-N- (4-氨磺酰基苯基)丙酰胺(MMH-1)。检测了化合物MMH-1对h CA I、II、IX、XII的抑制性能。测试了 MMH-1 对癌症和正常细胞的细胞毒作用,发现它选择性地影响 MDA-MB-231 细胞。
更新日期:2024-02-07
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