Stimuli-responsive polymersomes have been explored extensively as drug nanocarriers, nanoreactors, and artificial cells and organelles. However, the morphology of stimuli-responsive polymersomes has mainly been limited to spherical vesicles. In this work, we have reported the first example of biodegradable light-responsive tubular polymersomes based on the hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(trimethylene carbonate-azobenzene) [P(TMC-AZO)] amphiphilic diblock copolymer. The block copolymer PEG-b-P(TMC-AZO)_n was prepared via postpolymerization functionalization of poly(TMC-OC₆F₅) with AZO-amine. Light-responsive AZO-containing tubular polymersomes were obtained by optimizing the polymerization degree, water content, and ionic strength. The tubular polymersomes demonstrated photo-responsive behavior upon UV/Vis light irradiation, and the tubular structures were transformed to linear micelles upon light stimulation. These biodegradable tubular polymersomes are expected to have potential applications in nanomedicine, bio-inspired systems and responsive smart materials.

中文翻译：

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光响应性可生物降解管状聚合物囊泡的合成与表征

刺激响应聚合物囊泡已作为药物纳米载体、纳米反应器以及人造细胞和细胞器得到了广泛的探索。然而，刺激响应聚合物囊泡的形态主要限于球形囊泡。在这项工作中，我们报道了基于亲水性聚乙二醇（PEG）和疏水性聚（三亚甲基碳酸酯-偶氮苯）[P(TMC-AZO)]两亲性二嵌段共聚物的可生物降解光响应管状聚合物囊泡的第一个例子。嵌段共聚物PEG- b -P(TMC-AZO) _n通过聚(TMC-OC ₆ F ₅ )与AZO-胺的后聚合官能化制备。通过优化聚合度、含水量和离子强度，获得了光响应性含偶氮管状聚合物囊泡。管状聚合物囊泡在紫外/可见光照射下表现出光响应行为，并且管状结构在光刺激下转化为线性胶束。这些可生物降解的管状聚合物囊泡有望在纳米医学、仿生系统和响应性智能材料中具有潜在的应用。