In developing embryos, downregulation of lymphatic endothelial proliferation is needed for maturation of lymphatic vessels into a hierarchical network. In this issue of Developmental Cell, Carlantoni discover that phosphodiesterase2A controls lymphatic endothelial growth arrest and maturation via regulation of cGMP, p38 MAP kinase, and Notch pathway.

中文翻译：

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淋巴管生成生长停滞和成熟所必需的磷酸二酯酶途径

在发育中的胚胎中，淋巴管内皮增殖的下调是淋巴管成熟为分层网络所必需的。在本期《发育细胞》中，Carlantoni 发现磷酸二酯酶2A 通过调节 cGMP、p38 MAP 激酶和 Notch 通路来控制淋巴管内皮生长停滞和成熟。