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Compositional plasticity of the Atg1 complex
Nature Cell Biology ( IF 21.3 ) Pub Date : 2024-02-05 , DOI: 10.1038/s41556-023-01340-4
Xiaoli Ma , Hong Zhang

How do metabolic stresses trigger catabolic autophagy for cell survival? A study now reveals that the metabolite sensor Pho81 integrates into and activates the kinase activity of the Atg1 complex for pexophagy triggered by phosphate starvation. This demonstrates the plasticity of the autophagy-initiating Atg1 complex.

中文翻译:

Atg1 复合物的组成可塑性

代谢应激如何触发分解代谢自噬以促进细胞生存?现在的一项研究表明,代谢物传感器 Pho81 整合并激活 Atg1 复合物的激酶活性,以实现由磷酸盐饥饿引发的 pexophagy。这证明了自噬启动 Atg1 复合物的可塑性。
更新日期:2024-02-05
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