Antimetastatic agents are highly desirable for cancer treatment because of the severe medical challenges and high mortality resulting from tumor metastasis. Having demonstrated antimetastatic effects in numerous and studies, migration inhibitors present significant opportunities for developing a new class of anticancer drugs. To provide a useful overview on the latest research in migration inhibitors, this article first discusses their therapeutic significance, targetable proteins, and developmental avenues. Subsequently it reviews over 20 representative migration inhibitors reported in recent journals in terms of their inhibitory mechanism, potency, and potential clinical utility. The relevance of the target proteins to cellular migratory function is focused on as it is crucial for assessing the overall efficacy of the inhibitors.

中文翻译：

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最近报道的细胞迁移抑制剂：抗转移剂的机遇和挑战

由于肿瘤转移带来的严峻的医学挑战和高死亡率，抗转移剂对于癌症治疗来说是非常需要的。大量研究证明迁移抑制剂具有抗转移作用，为开发新型抗癌药物提供了重要机会。为了对迁移抑制剂的最新研究提供有用的概述，本文首先讨论了它们的治疗意义、可靶向蛋白质和发展途径。随后，它回顾了最近期刊报道的 20 多种具有代表性的迁移抑制剂的抑制机制、效力和潜在的临床实用性。靶蛋白与细胞迁移功能的相关性受到关注，因为它对于评估抑制剂的整体功效至关重要。