Background

This cohort study aimed to examine the relationship between objectively measured daily ambulatory activity (AA) variables and the onset of metabolic syndrome (MetS) in middle-aged and older Japanese individuals.

Methods

A total of 1,034 participants (women, 76.8%; mean age, 56.9 years) who were initially free from MetS, underwent objective assessment of daily AA using a uniaxial accelerometer at baseline. The number of steps, time accumulated in light-intensity AA (LIAA), moderate-to-vigorous intensity AA (MVAA), and total AA (LIAA + MVAA) were calculated. The diagnostic criteria outlined by the Japanese standards were employed to define the presence of MetS. To explore the association between AA variables and MetS onset, both multivariate logistic regression and a restricted cubic spline model were used while controlling for variables such as age, sex, education, alcohol habit, smoking habit, energy intake, and the number of MetS components present at baseline.

Results

Over the course of the 5-year follow-up period, 116 participants (11.2%) developed MetS. In terms of the number of steps, LIAA, and total AA, the third quartile had significantly lower multivariate adjusted odds ratios for MetS onset than the first quartile. The odds ratios (95% confidence intervals) were 0.386 (0.197–0.755), 0.527 (0.285–0.975), and 0.392 (0.206–0.745), respectively. In the spline model, an L-shaped association with MetS was observed for the number of steps (p for nonlinearity = 0.066), LIAA (p for nonlinearity = 0.034), and total AA (p for nonlinearity = 0.040).

Conclusions

Among the variables related to AA, the index of daily amount AA, in particular, may be linked to the onset of MetS.

中文翻译：

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日本中老年人每日步行活动与代谢综合征的前瞻性关联：Toon 健康研究

背景

这项队列研究旨在探讨日本中老年人客观测量的每日步行活动（AA）变量与代谢综合征（MetS）发病之间的关系。

方法

总共 1,034 名最初没有 MetS 的参与者（女性，76.8%；平均年龄，56.9 岁）在基线时使用单轴加速度计对每日 AA 进行了客观评估。计算步数、轻强度 AA (LIAA)、中强度 AA (MVAA) 和总 AA (LIAA + MVAA) 中累积的时间。采用日本标准概述的诊断标准来定义 MetS 的存在。为了探索 AA 变量与 MetS 发病之间的关联，使用多元逻辑回归和限制三次样条模型，同时控制年龄、性别、教育、饮酒习惯、吸烟习惯、能量摄入和 MetS 成分数量等变量存在于基线。

结果

在 5 年的随访期间，116 名参与者 (11.2%) 出现了 MetS。就步数、LIAA 和总 AA 而言，第三个四分位数的 MetS 发病多变量调整优势比显着低于第一个四分位数。比值比（95% 置信区间）分别为 0.386 (0.197–0.755)、0.527 (0.285–0.975) 和 0.392 (0.206–0.745)。在样条模型中，观察到步数（非线性 p = 0.066）、LIAA（非线性 p = 0.034）和总 AA（非线性 p = 0.040）与 MetS 呈 L 形关联。

结论

在与 AA 相关的变量中，特别是每日 AA 量的指数可能与 MetS 的发生有关。