Magnetic hyperthermia therapy (MHT) has garnered immense interest due to its exceptional spatiotemporal specificity, minimal invasiveness and remarkable tissue penetration depth. Nevertheless, the limited magnetothermal heating capability and the potential toxicity of metal ions in magnetic materials based on metallic elements significantly impede the advancement of MHT. Herein, we introduce the concept of nonmetallic materials, with graphite (Gra) as a proof of concept, as a highly efficient and biocompatible option for MHT of tumors in vivo for the first time. The Gra exhibits outstanding magnetothermal heating efficacy owing to the robust eddy thermal effect driven by its excellent electrical conductivity. Furthermore, being composed of carbon, Gra offers superior biocompatibility as carbon is an essential element for all living organisms. Additionally, the Gra boasts customizable shapes and sizes, low cost, and large-scale production capability, facilitating reproducible and straightforward manufacturing of various Gra implants. In a mouse tumor model, Gra-based MHT successfully eliminates the tumors at an extremely low magnetic field intensity, which is less than one-third of the established biosafety threshold. This study paves the way for the development of high-performance magnetocaloric materials by utilizing nonmetallic materials in place of metallic ones burdened with inherent limitations.

中文翻译：

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肿瘤磁热疗用非金属石墨

磁热疗（MHT）因其卓越的时空特异性、微创性和显着的组织穿透深度而引起了极大的兴趣。然而，基于金属元素的磁性材料中有限的磁热加热能力和金属离子的潜在毒性严重阻碍了MHT的发展。在此，我们引入非金属材料的概念，以石墨（Gra）作为概念证明，首次作为体内肿瘤 MHT 的高效且生物相容的选择。由于其优异的导电性驱动的强大涡流热效应，Gra 表现出出色的磁热加热功效。此外，Gra 由碳组成，具有卓越的生物相容性，因为碳是所有生物体的基本元素。此外，Gra 还拥有可定制的形状和尺寸、低成本和大规模生产能力，有助于各种 Gra 植入物的可重复和直接制造。在小鼠肿瘤模型中，基于 Gra 的 MHT 在极低的磁场强度下成功消除了肿瘤，该磁场强度低于既定生物安全阈值的三分之一。这项研究通过利用非金属材料代替具有固有局限性的金属材料，为高性能磁热材料的开发铺平了道路。