To find structurally previously undescribed compounds with pharmacological effects from (Roxb.) K. Schum (Rubiaceae), thirteen undescribed tetrahydroanthraquinones (⎼) named prisconnatanones J⎼V and seven known anthraquinones (⎼) were isolated and characterized. The structures of these compounds were elucidated by detailed spectroscopic analyses, and their absolute configurations were established by modified Mosher's method and ECD calculations. The antitumor cell proliferative activities of prisconnatanones J⎼V were determined. Among them, prisconnatanones J possessed high antitumor cell proliferation in HGC27 cells (IC, 0.792 μM) by blocking HGC27 cells in the S phase and significantly inducing apoptosis in HGC27 cells. Prisconnatanone J has no cytotoxicity to normal gastric cells line (GES-1) at 10 μM and showed a considerable selectivity for HGC27 cells. Prisconnatanone J can potentially inhibit tumor cell proliferation and should be further investigated.

中文翻译：

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以前未描述过的来自 Prismatomeris tetrandra (roxb.) K. Schum 的四氢蒽醌具有抗肿瘤细胞增殖活性

为了从 (Roxb.) K. Schum（茜草科）中找到结构上以前未描述的具有药理作用的化合物，分离并表征了 13 种未描述的四氢蒽醌 (⎼)，命名为 prisconatanones J⎼V 和 7 种已知的蒽醌 (⎼)。通过详细的光谱分析阐明了这些化合物的结构，并通过改进的 Mosher 方法和 ECD 计算确定了它们的绝对构型。测定了Prisconnatanones J⎼V的抗肿瘤细胞增殖活性。其中，Prisconnatanones J通过阻断HGC27细胞处于S期并显着诱导HGC27细胞凋亡，对HGC27细胞具有较高的抗肿瘤细胞增殖作用（IC50，0.792μM）。 10 μM 的 Prisconnatanone J 对正常胃细胞系 (GES-1) 无细胞毒性，并且对 HGC27 细胞显示出相当大的选择性。 Prisconnatanone J 可能抑制肿瘤细胞增殖，应进一步研究。