The temporal evolution of HRQoL and the importance of other PROs to patients, following resection for pancreatic and peripancreatic malignancy remains unexplored. Patients undergoing pancreatic resection between 2021 and 2022 were enrolled from 2 UK HPB centres. Patients completed the EORTC QLQ-C30, QLQ-PAN26 tools and rated 56 PROs preoperatively (T1), at discharge (T2), 6-weeks (T3), 3-months (T4) and 6-months (T5) postoperatively. ANOVA followed by post-hoc analysis was used to examine patterns in HRQoL through time. Multivariable ANOVA was used to identify impact of clinical factors on HRQoL. 63 patients were recruited [median age, 72 (IQR 41–85); 39/63 male]. Physical functioning declined from 70.4 (26.2) at T1 to 53.5 (20.9) at T2 (p = 0.016). Global QoL score increased significantly from 41.0 (23.0) at T2 to 60.0 (26.1) at T5 (p = 0.007), as did role functioning [21.1 (27.9) at T2 to 59.4 (32.8) at T5, p < 0.001]. Chemotherapy status and the postoperative complications did not significantly change HRQoL. General QoL and health were the only PROs rated as ‘very important’ (scores 7–9) by more than 80 % of participants at five time-points. Recuperation of HRQoL measures is seen at 6-months postoperative and was not affected by chemotherapy or postoperative complications. Notably, PROs important to patients varied over time.

中文翻译：

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对胰腺癌和胰周癌健康相关生活质量和患者相关结局的多中心前瞻性评估：PROMCAN 研究

胰腺和胰周恶性肿瘤切除后，HRQoL 的时间演变以及其他 PRO 对患者的重要性仍有待探索。2021 年至 2022 年期间接受胰腺切除术的患者来自英国 2 个 HPB 中心。患者在术前 (T1)、出院时 (T2)、术后 6 周 (T3)、3 个月 (T4) 和 6 个月 (T5) 完成 EORTC QLQ-C30、QLQ-PAN26 工具并评分 56 个 PRO。使用方差分析和事后分析来检查随时间变化的 HRQoL 模式。使用多变量方差分析来确定临床因素对 HRQoL 的影响。招募了 63 名患者 [中位年龄 72 岁 (IQR 41–85)；39/63 男]。身体功能从 T1 时的 70.4 (26.2) 下降到 T2 时的 53.5 (20.9) (p = 0.016)。总体生活质量评分从 T2 时的 41.0 (23.0) 显着增加至 T5 时的 60.0 (26.1) (p = 0.007)，角色功能也显着增加 [T2 时的 21.1 (27.9) 至 T5 时的 59.4 (32.8)，p < 0.001]。化疗状态和术后并发症没有显着改变 HRQoL。一般生活质量和健康是唯一在五个时间点被超过 80% 的参与者评为“非常重要”（得分 7-9）的 PRO。术后 6 个月即可观察到 HRQoL 指标的恢复，并且不受化疗或术后并发症的影响。值得注意的是，对患者重要的 PRO 随着时间的推移而变化。