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Recent trends in the delivery of RNA drugs: Beyond the liver, more than vaccine
European Journal of Pharmaceutics and Biopharmaceutics ( IF 4.4 ) Pub Date : 2024-02-01 , DOI: 10.1016/j.ejpb.2024.114203 Marwa G Elnaggar 1 , Yanying He 2 , Yoon Yeo 3
European Journal of Pharmaceutics and Biopharmaceutics ( IF 4.4 ) Pub Date : 2024-02-01 , DOI: 10.1016/j.ejpb.2024.114203 Marwa G Elnaggar 1 , Yanying He 2 , Yoon Yeo 3
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RNAs are known for versatile functions and therapeutic utility. They have gained significant interest since the approval of several RNA drugs, including COVID-19 mRNA vaccines and therapeutic agents targeting liver diseases. There are increasing expectations for a new class of RNA drugs for broader applications. Successful development of RNA drugs for new applications hinges on understanding their diverse functions and structures. In this review, we explore the last five years of literature to understand current approaches to formulate a spectrum of RNA drugs, focusing on new efforts to expand their applications beyond vaccines and liver diseases.
中文翻译：
RNA 药物输送的最新趋势：超越肝脏，不仅仅是疫苗
RNA 以其多种功能和治疗用途而闻名。自从多种 RNA 药物（包括 COVID-19 mRNA 疫苗和针对肝病的治疗药物）获得批准以来，他们引起了极大的兴趣。人们对新型 RNA 药物的更广泛应用的期望越来越高。 RNA 药物新应用的成功开发取决于对其不同功能和结构的了解。在这篇综述中，我们探讨了过去五年的文献，以了解目前配制一系列 RNA 药物的方法，重点关注将其应用扩展到疫苗和肝脏疾病之外的新努力。
更新日期：2024-02-01
中文翻译：
RNA 药物输送的最新趋势：超越肝脏，不仅仅是疫苗
RNA 以其多种功能和治疗用途而闻名。自从多种 RNA 药物（包括 COVID-19 mRNA 疫苗和针对肝病的治疗药物）获得批准以来，他们引起了极大的兴趣。人们对新型 RNA 药物的更广泛应用的期望越来越高。 RNA 药物新应用的成功开发取决于对其不同功能和结构的了解。在这篇综述中，我们探讨了过去五年的文献，以了解目前配制一系列 RNA 药物的方法，重点关注将其应用扩展到疫苗和肝脏疾病之外的新努力。
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