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Glymphatic-stagnated edema induced by traumatic brain injury
Trends in Pharmacological Sciences ( IF 13.8 ) Pub Date : 2024-01-29 , DOI: 10.1016/j.tips.2024.01.005
Per Kristian Eide , Geir Ringstad

Traumatic brain injury (TBI) outcomes are notably affected by brain edema. A recent report by Hussain et al. unveils a unique form, glymphatic-stagnated brain edema, that stems from impaired glymphatic and lymphatic drainage induced by noradrenergic activation. Consequently, pan-noradrenergic inhibition may emerge as an innovative treatment for TBI-related edema, challenging traditional therapeutic approaches.



中文翻译:

脑外伤引起的淋巴停滞性水肿

创伤性脑损伤(TBI)的结果尤其受到脑水肿的影响。侯赛因等人最近的一份报告揭示了一种独特的形式,即类淋巴停滞性脑水肿,其源于去甲肾上腺素能激活引起的类淋巴和淋巴引流受损。因此,全去甲肾上腺素能抑制可能成为治疗 TBI 相关水肿的创新疗法,对传统治疗方法提出挑战。

更新日期:2024-01-29
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