Cancer cells often rely on glycolysis for energy metabolism. Increased glycolysis leads to the increased production of lactate and H+ ions, which should hypothetically lower intracellular pH. However, we find that tumor cells combat intracellular over-acidification by synthesizing carnosine, especially under hypoxic conditions, which allows them to control lysosome-dependent galectin-9 expression and evade T cell-mediated immune surveillance.

中文翻译：

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肌肽通过调节细胞内 pH 值帮助癌细胞逃避免疫监视

癌细胞通常依靠糖酵解进行能量代谢。糖酵解的增加会导致乳酸和 H+ 离子的产生增加，这应该会降低细胞内的 pH 值。然而，我们发现肿瘤细胞通过合成肌肽来对抗细胞内过度酸化，特别是在缺氧条件下，这使得它们能够控制溶酶体依赖性半乳糖凝集素9的表达并逃避T细胞介导的免疫监视。