Protein nanopores are an established technology for nucleic acid sequencing. There has also been recent progress in using nanopores for amino acid sequencing and profiling post-translational modifications of proteins, but such developments lag for glycans. Zhang et al. have now demonstrated that it is possible to distinguish between disaccharides using a modified protein nanopore based on Mycobacterium smegmatis porin A (MspA) and machine learning to analyze the data.

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纳米孔聚糖分析

蛋白质纳米孔是一种成熟的核酸测序技术。最近在使用纳米孔进行氨基酸测序和分析蛋白质翻译后修饰方面也取得了进展，但聚糖的发展滞后。张等人。现在已经证明，使用基于耻垢分枝杆菌孔蛋白 A (MspA) 的修饰蛋白纳米孔和机器学习来分析数据，可以区分二糖。