N⁶-methyladenosine (m⁶A) is an abundant mRNA modification that affects the properties of RNA and m⁶A dysregulation contributes to several diseases. The machinery that affects m⁶A processing is therefore a promising therapeutic target; however, methods that enable monitoring of m⁶A modifications require isolation of RNA and so cannot provide a real-time readout of mRNA methylation in living cells. Now, Marayati et al. have developed a genetically encoded m⁶A sensor called GEMS, which provides an easily detected fluorescent signal in response to cellular mRNA methylation.

中文翻译：

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阐明 mRNA 修饰

N ⁶ -甲基腺苷 (m ⁶ A) 是一种丰富的 mRNA 修饰，会影响 RNA 的特性，m ⁶ A 失调会导致多种疾病。^{因此，影响 m 6} A 加工的机制是一个有前途的治疗靶点；然而，能够监测 m ⁶ A 修饰的方法需要分离 RNA，因此无法提供活细胞中 mRNA 甲基化的实时读数。现在，Marayati 等人。开发了一种称为 GEMS 的基因编码 m ⁶ A 传感器，它可以响应细胞 mRNA 甲基化提供易于检测的荧光信号。