Objective To describe the long-term consequences of necrotising pancreatitis, including complications, the need for interventions and the quality of life. Design Long-term follow-up of a prospective multicentre cohort of 373 necrotising pancreatitis patients (2005–2008) was performed. Patients were prospectively evaluated and received questionnaires. Readmissions (ie, for recurrent or chronic pancreatitis), interventions, pancreatic insufficiency and quality of life were compared between initial treatment groups: conservative, endoscopic/percutaneous drainage alone and necrosectomy. Associations of patient and disease characteristics during index admission with outcomes during follow-up were assessed. Results During a median follow-up of 13.5 years (range 12–15.5 years), 97/373 patients (26%) were readmitted for recurrent pancreatitis. Endoscopic or percutaneous drainage was performed in 47/373 patients (13%), of whom 21/47 patients (45%) were initially treated conservatively. Pancreatic necrosectomy or pancreatic surgery was performed in 31/373 patients (8%), without differences between treatment groups. Endocrine insufficiency (126/373 patients; 34%) and exocrine insufficiency (90/373 patients; 38%), developed less often following conservative treatment (p<0.001 and p=0.016, respectively). Quality of life scores did not differ between groups. Pancreatic gland necrosis >50% during initial admission was associated with percutaneous/endoscopic drainage (OR 4.3 (95% CI 1.5 to 12.2)), pancreatic surgery (OR 3.2 (95% CI 1.1 to 9.5) and development of endocrine insufficiency (OR13.1 (95% CI 5.3 to 32.0) and exocrine insufficiency (OR6.1 (95% CI 2.4 to 15.5) during follow-up. Conclusion Acute necrotising pancreatitis carries a substantial disease burden during long-term follow-up in terms of recurrent disease, the necessity for interventions and development of pancreatic insufficiency, even when treated conservatively during the index admission. Extensive (>50%) pancreatic parenchymal necrosis seems to be an important predictor of interventions and complications during follow-up. Data are available on reasonable request from the corresponding author.

中文翻译：

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坏死性胰腺炎的长期随访研究：干预措施、并发症和生活质量

目的 描述坏死性胰腺炎的长期后果，包括并发症、干预的必要性和生活质量。设计 对 373 名坏死性胰腺炎患者（2005-2008 年）进行了前瞻性多中心队列的长期随访。对患者进行前瞻性评估并接受问卷调查。比较初始治疗组（保守治疗组、单纯内镜/经皮引流术和坏死切除术）的再入院率（即复发性或慢性胰腺炎）、干预措施、胰腺功能不全和生活质量。评估了入院期间患者和疾病特征与随访期间结果的关联。结果 在中位随访 13.5 年（范围 12-15.5 年）期间，97/373 名患者 (26%) 因复发性胰腺炎再次入院。 47/373 名患者（13%）进行了内镜或经皮引流，其中 21/47 名患者（45%）最初接受了保守治疗。 31/373 名患者 (8%) 接受了胰腺坏死切除术或胰腺手术，治疗组之间没有差异。保守治疗后，内分泌功能不全（126/373 名患者；34%）和外分泌功能不全（90/373 名患者；38%）发生率较低（分别为 p<0.001 和 p=0.016）。各组之间的生活质量得分没有差异。初次入院时胰腺坏死>50%与经皮/内镜引流（OR 4.3（95% CI 1.5至12.2））、胰腺手术（OR 3.2（95% CI 1.1至9.5）和内分泌功能不全（OR13.5）相关。随访期间为1（95% CI 5.3 - 32.0）和外分泌功能不全（OR6.1（95% CI 2.4 - 15.5））。结论 急性坏死性胰腺炎在长期随访期间复发性疾病带来了巨大的疾病负担，干预的必要性和胰腺功能不全的发展，即使在入院期间进行保守治疗。广泛（> 50％）胰腺实质坏死似乎是随访期间干预和并发症的重要预测因素。可根据合理要求提供数据来自通讯作者。