Sumalarins D–G (1–4), four previously undescribed curvularin derivatives, along with two known related metabolites, curvularin (5) and dehydrocurvularin (6), were isolated and identified from the mangrove-derived fungus Penicillium sumatrense MA-325. Among them, sumalarin D (1) represents a unique example of curvularin derivative featuring a 5-methylfuran-2-yl-methyl group. Their structures were elucidated based on analysis of NMR and MS data as well as comparison of ECD spectra and quantum chemical calculations of NMR, and compound 1 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, 5, and 6 are active against aquatic pathogenic bacteria Vibrio alginolyticus and V. harveyi with MIC values ranging from 4 to 64 μg/mL, while compound 6 is cytotoxic against tumor cell lines 5673, HCT 116, 786-O, and Hela with IC₅₀ values of 3.5, 10.6, 10.9, and 14.9 μM, respectively.

Sumalarins D–G ( 1 – 4 )是从红树林来源的真菌Penicillium sumatrense MA-325 中分离并鉴定出的四种先前未描述的 curvularin 衍生物，以及两种已知的相关代谢物 curvularin ( 5 ) 和脱氢curvularin ( 6 ) 。其中，sumalarin D ( 1 )代表了具有5-甲基呋喃-2-基-甲基基团的curvularin衍生物的独特实例。通过对NMR和MS数据的分析以及ECD谱的比较和NMR的量子化学计算，阐明了它们的结构，并通过X射线晶体学分析证实了化合物1 。化合物1、2、5和6对水生病原菌溶藻弧菌和哈维弧菌具有活性，MIC 值范围为 4 至 64 μg/mL，而化合物6对肿瘤细胞系 5673 、HCT 116、786-O 具有细胞毒性和 Hela，IC ₅₀值分别为 3.5、10.6、10.9 和 14.9 μM。