A fluorescent dansyl-based amphiphilic probe, 5-(dimethylamino)-N-hexadecylnaphthalene-1-sulfonamide (), was synthesized and characterized to detect multiple analytes at different sensing environments. In acetonitrile, detects nitro explosives such as trinitrophenol (TNP) and 2,4-dinitrophenol (2,4-DNP) by an emission “on-off” response method, and the detection limits (LOD) were estimated to be as low as 4.3 µM and 17.4 µM, respectively. Amphiphilic long chains of the probe were embedded into lipid bilayers to form nanoscale vesicles . Nanovesicular probe was found to be highly selective for Hg among other metal ions and for pyrophosphate (PPi) ions among various anions. could detect Hg with a turn “on–off” emission and PPi with ratiometric change in emission at 525 nm. It is proposed that could detect Hg via the Hg-induced aggregation quenching mechanism and PPi through the Hydrogen bonding. The LODs are estimated as 6.41 µM and 70.9 µM for Hg and PPi, respectively. H NMR, SEM, and fluorescence lifetime measurements confirmed the binding mechanism. Thus, it is believed that the simple fluorescent probe could be a prominent sensor to detect multiple analytes depending on the sensing medium.

中文翻译：

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用于检测 Hg2+、PPi 和 TNP 的两亲性丹磺酰多分析物传感器：三合一化学传感器

合成并表征了一种基于荧光丹酰基的两亲性探针 5-(二甲氨基)-N-十六烷基萘-1-磺酰胺 ()，用于在不同传感环境下检测多种分析物。在乙腈中，通过排放“开关”响应方法检测三硝基苯酚 (TNP) 和 2,4-二硝基苯酚 (2,4-DNP) 等硝基爆炸物，检测限 (LOD) 估计低至分别为 4.3 µM 和 17.4 µM。探针的两亲性长链嵌入脂质双层中形成纳米级囊泡。研究发现纳米囊泡探针对其他金属离子中的汞和各种阴离子中的焦磷酸 (PPi) 离子具有高度选择性。可以通过“开关”发射来检测 Hg，并通过 525 nm 处的发射比率变化来检测 PPi。建议通过Hg诱导的聚集猝灭机制检测Hg，通过氢键检测PPi。 Hg 和 PPi 的 LOD 估计分别为 6.41 µM 和 70.9 µM。 H NMR、SEM 和荧光寿命测量证实了结合机制。因此，据信简单的荧光探针可以是根据传感介质检测多种分析物的重要传感器。