A ketogenic diet (KD) characterized by very low carbohydrate intake and high fat consumption may simultaneously induce weight loss and be cardioprotective. The “thrifty substrate hypothesis” posits that ketone bodies are more energy efficient compared with other cardiac oxidative substrates such as fatty acids. This work aimed to study whether a KD with presumed increased myocardial ketone body utilization reduces cardiac fatty acid uptake and oxidation, resulting in decreased myocardial oxygen consumption (MVO₂).

中文翻译：

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生酮饮食降低心肌脂肪酸氧化但不影响耗氧量：一项针对超重人群的研究

以极低碳水化合物摄入和高脂肪消耗为特征的生酮饮食（KD）可以同时减轻体重并保护心脏。“节俭底物假说”认为，与脂肪酸等其他心脏氧化底物相比，酮体的能量效率更高。这项工作旨在研究推测心肌酮体利用率增加的生酮饮食是否会减少心脏脂肪酸的摄取和氧化，从而导致心肌耗氧量（MVO ₂）减少。