Sleep-related painful erection (SRPE) is a condition characterized by painful nocturnal erections and frequent nighttime awakenings; however, the pathophysiology is not well understood and existing literature consists mainly of case reports. We aimed to investigate the causes, treatments, and impact on quality of life among individuals affected by SRPE. An e-questionnaire comprising of 30 items was administered to a group of men with SRPE identified through social media in October of 2021. The survey collected information on demographics, clinical and social history, symptomatology, interventions and quality of life. 44 patients with SRPE completed surveys (70.9% response rate), with a mean age ± SD of 43.3 ± 12.8 years. Most respondents had no relevant medical history related to erectile function disorders. 43.2% of subjects reported sleep apnea, and 27.1% reported a mental health disorder or psychiatric medication use. Baclofen was the most common medication, but only 25% of patients found it beneficial. Sleep repositioning, oxygen device use and pelvic floor therapy were interventions that provided the most relief. Most patients did not require emergency department visits (93.2%); only a small number needed penile aspiration (n = 2). As reported by most respondents, SRPE significantly impacted patients’ quality of life.

睡眠相关的勃起疼痛 (SRPE) 是一种以夜间勃起疼痛和频繁夜间醒来为特征的疾病；然而，其病理生理学尚不清楚，现有文献主要由病例报告组成。我们的目的是调查 SRPE 患者的原因、治疗方法及其对生活质量的影响。2021 年 10 月，对通过社交媒体识别出的一组患有 SRPE 的男性进行了一份包含 30 个项目的电子问卷。该调查收集了有关人口统计、临床和社会史、症状、干预措施和生活质量的信息。44 名 SRPE 患者完成了调查（响应率为 70.9%），平均年龄 ± SD 为 43.3 ± 12.8 岁。大多数受访者没有与勃起功能障碍相关的病史。43.2% 的受试者报告有睡眠呼吸暂停，27.1% 的受试者报告有精神健康障碍或使用精神药物。巴氯芬是最常见的药物，但只有 25% 的患者认为它有益。睡眠重新定位、使用氧气装置和盆底治疗是最能缓解疼痛的干预措施。大多数患者不需要急诊室就诊（93.2%）；只有少数人需要进行阴茎抽吸术（n  = 2）。大多数受访者表示，SRPE 显着影响患者的生活质量。