Although mechanical cues are known to influence the postnatal skeleton, the impact of bone cell mechano-transduction on early skeletal development remains less clear. In this issue of Developmental Cell, Collins et al. (2023) report that YAP/TAZ deletion in osteoblast precursors reduces Cxcl12 expression, leading to defects in bone vascularization.

中文翻译：

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血液和骨骼：机械线索和河马信号在肢体形成过程中驱动血管入侵

尽管已知机械信号会影响出生后骨骼，但骨细胞机械转导对早期骨骼发育的影响仍不太清楚。在本期《发育细胞》中，柯林斯等人。(2023) 报告称，成骨细胞前体中的 YAP/TAZ 缺失会降低 Cxcl12 的表达，导致骨血管化缺陷。