Cold exposure modulates potential brown adipokines in humans, but only FGF21 is associated with brown adipose tissue volume,Obesity

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Cold exposure modulates potential brown adipokines in humans, but only FGF21 is associated with brown adipose tissue volume
Obesity ( IF 6.9 ) Pub Date : 2024-01-22 , DOI: 10.1002/oby.23970
Andrea Mendez‐Gutierrez _{1,

2,

3,

4} , Concepcion M. Aguilera _{1,

2,

3,

4} , Rubén Cereijo _{4,

5} , Francisco J. Osuna‐Prieto _{6,

7} , Borja Martinez‐Tellez _{4,

7,

8,

9,

10} , Maria C. Rico _{1,

2} , David Sanchez‐Infantes _{4,

11} , Francesc Villarroya _{4,

5} , Jonatan R. Ruiz _{3,

4,

7} , Guillermo Sanchez‐Delgado _{2,

4,

7,

12,

13}

Affiliation

Department of Biochemistry and Molecular Biology II University of Granada Granada Spain
“José Mataix Verdú” Institute of Nutrition and Food Technology (INYTA), Center of Biomedical Research University of Granada Granada Spain
Instituto de Investigación Biosanitaria Granada Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, Sant Joan de Déu Research Institute University of Barcelona Barcelona Spain
Hospital Universitari Joan XXIII de Tarragona Institut d'Investigació Sanitària Pere Virgili (IISPV) Tarragona Spain
Department of Physical Education and Sports, Faculty of Sports Science Sport and Health University Research Institute (iMUDS), University of Granada Granada Spain
Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands
Department of Education, Faculty of Education Sciences and SPORT Research Group (CTS‐1024), CERNEP Research Center University of Almería Almería Spain
Department of Health Sciences, Campus Alcorcón University Rey Juan Carlos (URJC) Madrid Spain
Pennington Biomedical Research Center Baton Rouge Louisiana USA
Department of Medicine, Division of Endocrinology, Centre de recherche du Centre Hospitalier de Sherbrooke Université de Sherbrooke Sherbrooke Quebec Canada

The study objective was to investigate the effect of cold exposure on the plasma levels of five potential human brown adipokines (chemokine ligand 14 [CXCL14], growth differentiation factor 15 [GDF15], fibroblast growth factor 21 [FGF21], interleukin 6 [IL6], and bone morphogenic protein 8b [BMP8b]) and to study whether such cold-induced effects are related to brown adipose tissue (BAT) volume, activity, or radiodensity in young humans.

中文翻译：

冷暴露会调节人类潜在的棕色脂肪因子，但只有 FGF21 与棕色脂肪组织体积相关

研究目的是研究冷暴露对五种潜在人类棕色脂肪因子（趋化因子配体 14 [CXCL14]、生长分化因子 15 [GDF15]、成纤维细胞生长因子 21 [FGF21]、白细胞介素 6 [IL6] 血浆水平的影响，和骨形态发生蛋白 8b [BMP8b]），并研究这种寒冷引起的影响是否与年轻人的棕色脂肪组织 (BAT) 体积、活性或放射密度有关。

更新日期：2024-01-22

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