Background and Hypothesis Corollary discharge (CD) signals are “copies” of motor signals sent to sensory areas to predict the corresponding input. They are a posited mechanism enabling one to distinguish actions generated by oneself vs external forces. Consequently, altered CD is a hypothesized mechanism for agency disturbances in psychosis. Previous studies have shown a decreased influence of CD signals on visual perception in individuals with schizophrenia—particularly in those with more severe positive symptoms. We therefore hypothesized that altered CD may be a trans-diagnostic mechanism of psychosis. Study Design We examined oculomotor CD (using the blanking task) in 49 participants with schizophrenia or schizoaffective disorder (SZ), 36 bipolar participants with psychosis (BPP), and 40 healthy controls (HC). Participants made a saccade to a visual target. Upon saccade initiation, the target disappeared and reappeared at a horizontally displaced position. Participants indicated the direction of displacement. With intact CD, participants can make accurate perceptual judgements. Otherwise, participants may use saccade landing site as a proxy of pre-saccadic target to inform perception. Thus, multi-level modeling was used to examine the influence of target displacement and saccade landing site on displacement judgements. Study Results SZ and BPP were equally less sensitive to target displacement than HC. Moreover, regardless of diagnosis, SZ and BPP with more severe positive symptoms were more likely to rely on saccade landing site. Conclusions These results suggest that altered CD may be a trans-diagnostic mechanism of psychosis.

中文翻译：

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异常动眼神经放电信号作为精神病的跨诊断机制

背景和假设 推论放电（CD）信号是发送到感觉区域以预测相应输入的运动信号的“副本”。它们是一种假定的机制，使人们能够区分自己产生的行为与外部力量产生的行为。因此，CD 的改变是精神病中代理障碍的一种假设机制。先前的研究表明，CD 信号对精神分裂症患者视觉感知的影响有所减弱，尤其是那些具有更严重阳性症状的患者。因此，我们假设 CD 改变可能是精神病的跨诊断机制。研究设计 我们检查了 49 名精神分裂症或分裂情感障碍 (SZ) 参与者、36 名患有精神病 (BPP) 的双相情感障碍参与者和 40 名健康对照 (HC) 的动眼神经 CD（使用空白任务）。参与者对视觉目标进行扫视。扫视启动后，目标消失并重新出现在水平位移位置。参与者指出了位移的方向。有了完整的CD，参与者就可以做出准确的感性判断。否则，参与者可以使用扫视着陆点作为扫视前目标的代理来告知感知。因此，采用多层次建模来检验目标位移和扫视着陆点对位移判断的影响。研究结果 SZ 和 BPP 对目标位移的敏感度同样低于 HC。此外，无论诊断如何，具有更严重阳性症状的 SZ 和 BPP 更有可能依赖眼跳着陆部位。结论 这些结果表明 CD 改变可能是精神病的跨诊断机制。