Platelets play a critical role as circulating cells in the human body and contribute to essential physiological processes such as blood clotting, hemostasis, vascular repair, and thrombus formation. Currently, platelets are extensively employed in the development of innovative biomimetic drug delivery systems, offering significant enhancements in circulation time, biocompatibility, and targeted delivery efficiency compared to conventional drug delivery approaches. Leveraging the unique physiological functions of platelets, these platelet-derived drug delivery systems (DDSs) hold great promise for the treatment of diverse diseases, including cancer, cardiovascular diseases, infectious diseases, wound healing and other diseases. This review primarily focuses on the design and characteristics of existing platelet-derived DDSs, including their preparation and characterization methods. Furthermore, this review comprehensively outlines the applications of these materials across various diseases, offering a holistic understanding of their therapeutic potential. This study aimed to provide a comprehensive overview of the potential value of these materials in clinical treatment, serving as a valuable reference for the advancement of novel platelet-derived DDSs and their broader utilization in the field of disease treatment.

中文翻译：

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血小板衍生药物输送系统：癌症、心血管疾病、传染病等的开创性治疗


血小板作为人体内的循环细胞发挥着至关重要的作用，有助于凝血、止血、血管修复和血栓形成等基本生理过程。目前，血小板广泛用于开发创新的仿生药物递送系统，与传统的药物递送方法相比，可显着提高循环时间、生物相容性和靶向递送效率。利用血小板独特的生理功能，这些血小板衍生的药物递送系统（DDS）在治疗多种疾病方面具有广阔的前景，包括癌症、心血管疾病、传染病、伤口愈合和其他疾病。本综述主要关注现有血小板衍生 DDS 的设计和特性，包括其制备和表征方法。此外，这篇综述全面概述了这些材料在各种疾病中的应用，提供了对其治疗潜力的全面了解。本研究旨在全面概述这些材料在临床治疗中的潜在价值，为新型血小板衍生DDS的进步及其在疾病治疗领域的更广泛应用提供有价值的参考。