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Nanotherapeutics for prostate cancer treatment: A comprehensive review
Biomaterials ( IF 12.8 ) Pub Date : 2024-01-16 , DOI: 10.1016/j.biomaterials.2024.122469 Ruimin Hu 1 , Jin Lan 2 , Dinglin Zhang 3 , Wenhao Shen 4
Biomaterials ( IF 12.8 ) Pub Date : 2024-01-16 , DOI: 10.1016/j.biomaterials.2024.122469 Ruimin Hu 1 , Jin Lan 2 , Dinglin Zhang 3 , Wenhao Shen 4
Affiliation
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Prostate cancer (PCa) is the most prevalent solid organ malignancy and seriously affects male health. The adverse effects of prostate cancer therapeutics can cause secondary damage to patients. Nanotherapeutics, which have special targeting abilities and controlled therapeutic release profiles, may serve as alternative agents for PCa treatment. At present, many nanotherapeutics have been developed to treat PCa and have shown better treatment effects in animals than traditional therapeutics. Although PCa nanotherapeutics are highly attractive, few successful cases have been reported in clinical practice. To help researchers design valuable nanotherapeutics for PCa treatment and avoid useless efforts, herein, we first reviewed the strategies and challenges involved in prostate cancer treatment. Subsequently, we presented a comprehensive review of nanotherapeutics for PCa treatment, including their targeting methods, controlled release strategies, therapeutic approaches and mechanisms. Finally, we proposed the future prospects of nanotherapeutics for PCa treatment.
中文翻译：
前列腺癌纳米疗法：综合综述
前列腺癌（PCa）是最常见的实体器官恶性肿瘤，严重影响男性健康。前列腺癌治疗的副作用可能会对患者造成二次伤害。纳米疗法具有特殊的靶向能力和受控的治疗释放曲线，可以作为前列腺癌治疗的替代药物。目前，已经开发出许多纳米疗法来治疗前列腺癌，并在动物身上显示出比传统疗法更好的治疗效果。尽管PCa纳米疗法极具吸引力，但在临床实践中鲜有成功案例报道。为了帮助研究人员设计有价值的纳米疗法来治疗前列腺癌并避免无用的努力，我们首先回顾了前列腺癌治疗中涉及的策略和挑战。随后，我们对前列腺癌纳米治疗药物进行了全面综述，包括其靶向方法、控释策略、治疗方法和机制。最后，我们提出了纳米疗法治疗PCa的未来前景。
更新日期：2024-01-16
中文翻译：
前列腺癌纳米疗法：综合综述
前列腺癌（PCa）是最常见的实体器官恶性肿瘤，严重影响男性健康。前列腺癌治疗的副作用可能会对患者造成二次伤害。纳米疗法具有特殊的靶向能力和受控的治疗释放曲线，可以作为前列腺癌治疗的替代药物。目前，已经开发出许多纳米疗法来治疗前列腺癌，并在动物身上显示出比传统疗法更好的治疗效果。尽管PCa纳米疗法极具吸引力，但在临床实践中鲜有成功案例报道。为了帮助研究人员设计有价值的纳米疗法来治疗前列腺癌并避免无用的努力，我们首先回顾了前列腺癌治疗中涉及的策略和挑战。随后，我们对前列腺癌纳米治疗药物进行了全面综述，包括其靶向方法、控释策略、治疗方法和机制。最后，我们提出了纳米疗法治疗PCa的未来前景。
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