Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) is a highly conserved eukaryotic enzyme discovered as a key regulator of cellular energy homeostasis, with anti-inflammation, antioxidative stress, anticancer, and antifibrosis beneficial effects. AMPK is dysregulated in human pulmonary diseases such as acute lung injury, nonsmall cell lung cancer, pulmonary fibrosis, chronic obstructive pulmonary disease, and asthma. This review provides an overview of the beneficial role of natural, synthetic, and Chinese traditional medicines AMPK modulators in pulmonary diseases, and highlights the role of the AMPK signaling pathway in the lung, emphasizing the importance of finding lead compounds and drugs that can target and modulate AMPK to treat the lung diseases.

中文翻译：

---

使用合成化合物和天然产物的临床前证据表明 AMPK 是治疗肺部疾病的潜在药理学靶点

5′-单磷酸腺苷 (AMP) 激活蛋白激酶 (AMPK) 是一种高度保守的真核酶，被发现是细胞能量稳态的关键调节因子，具有抗炎、抗氧化应激、抗癌和抗纤维化的有益作用。 AMPK 在人类肺部疾病中失调，例如急性肺损伤、非小细胞肺癌、肺纤维化、慢性阻塞性肺病和哮喘。这篇综述概述了天然、合成和中药 AMPK 调节剂在肺部疾病中的有益作用，并强调了 AMPK 信号通路在肺部的作用，强调了寻找能够靶向和治疗肺部疾病的先导化合物和药物的重要性。调节 AMPK 来治疗肺部疾病。