The bone serves as an energy reservoir and actively engages in whole-body energy metabolism. Numerous studies have determined fuel requirements and bioenergetic properties of bone under physiological conditions as well as the dysregulation of energy metabolism associated with bone metabolic diseases. Here, we review the main sources of energy in bone cells and their regulation, as well as the endocrine role of the bone in systemic energy homeostasis. Moreover, we discuss metabolic changes that occur as a result of osteoporosis. Exploration in this area will contribute to an enhanced comprehension of bone energy metabolism, presenting novel possibilities to address metabolic diseases.

骨骼作为能量储存库并积极参与全身能量代谢。许多研究已经确定了生理条件下骨骼的燃料需求和生物能特性以及与骨代谢疾病相关的能量代谢失调。在这里，我们回顾了骨细胞的主要能量来源及其调节，以及骨骼在全身能量稳态中的内分泌作用。此外，我们还讨论了骨质疏松症导致的代谢变化。该领域的探索将有助于增强对骨能量代谢的理解，为解决代谢疾病提供新的可能性。