This paper presents the recrystallization of sodium bicarbonate (NaHCO₃) using the Supercritical AntiSolvent process. The focus is pointed toward crystal habit and its modification induced by varying the solvent nature. The observed habit is uncommon with crystals exhibiting a “zigzag” shape. High Resolution Scanning Electron Microscopy observations refuted that this shape was due to particle attachment: those “zigzag” particles are likely monocrystals grown in a diffusion-limited media. Firstly, a molecular modeling study shed light on organic solvents that can interact strongly with NaHCO₃ crystals. Such solvents were found to be ethylene glycol and glycine, in contrast to ethanol or water which likely interact weakly with NaHCO₃ crystals. An experimental campaign confirmed the predicted interactions. Ethylene glycol interactions with NaHCO₃ crystals led to the production of a different crystal salt. Alternatively, adding glycine as a growth inhibitor led to the initial polymorphic form, although with a modified growth mechanism.

本文介绍了使用超临界反溶剂工艺进行碳酸氢钠 (NaHCO _{3 ) 的重结晶。}重点是晶体习性及其因改变溶剂性质而引起的改变。观察到的习惯对于呈现“之字形”形状的晶体来说并不常见。高分辨率扫描电子显微镜观察反驳说，这种形状是由于颗粒附着造成的：那些“之字形”颗粒很可能是在扩散限制介质中生长的单晶。_{首先，分子模型研究揭示了可以与 NaHCO 3}晶体发生强烈相互作用的有机溶剂。_{发现这样的溶剂是乙二醇和甘氨酸，与可能与NaHCO 3}晶体弱相互作用的乙醇或水相反。一项实验活动证实了预测的相互作用。乙二醇与NaHCO ₃晶体相互作用导致产生不同的晶体盐。或者，添加甘氨酸作为生长抑制剂导致最初的多晶型，尽管生长机制有所改变。