To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relationship between biochemical markers involved with tissue turnover and inflammation and BMLs on MRI. Data from the Foundation for the National Institutes of Health OA Biomarkers Consortium within the Osteoarthritis Initiative (n = 600) was analyzed. BMLs were measured according to the MRI Osteoarthritis Knee Score (MOAKS) system (0–3), in 15 knee subregions. Serum and urinary biochemical markers assessed were as follows: serum C-terminal crosslinked telopeptide of type I collagen (CTX-I), serum crosslinked N-telopeptide of type I collagen (NTX-I), urinary CTX-Iα and CTX-Iβ, urinary NTX-I, urinary C-terminal cross-linked telopeptide of type II collagen (CTX-II), serum matrix metalloproteinase (MMP)-degraded type I, II, and III collagen (C1M, C2M, C3M), serum high sensitivity propeptide of type IIb collagen (hsPRO-C2), and matrix metalloproteinase-generated neoepitope of C-reactive protein (CRPM). The association between change in biochemical markers over 12 months and BMLs over 24 months was examined using regression models adjusted for covariates. The relationship between C1M, C2M, C3M, hsPRO-C2, and CRPM and BMLs at baseline and over 24 months was examined. Increases in serum CTX-I and urinary CTX-Iβ over 12 months were associated with increased odds of changes in the number of subregions affected by any BML at 24 months. Increase in hsPRO-C2 was associated with decreased odds of worsening in the number of subregions affected by any BML over 24 months. C1M and C3M were associated with BMLs affected at baseline. Short-term changes in serum CTX-I, hsPRO-C2, and urinary CTX-Iβ hold the potential to be prognostic of BML progression on MRI. The association of C1M and C3M with baseline BMLs on MRI warrants further investigation.

中文翻译：

---

生化标志物与骨髓病变成像变化的关联——数据来自美国国立卫生研究院骨关节炎生物标志物联盟基金会

评估 24 个月内与膝骨关节炎 (OA) MRI 上的骨髓病变 (BML) 相关的生化标记物的短期变化的预后价值，此外，评估与组织更新和骨关节炎相关的生化标记物之间的关系。 MRI 上的炎症和 BML。对美国国立卫生研究院 OA 生物标志物联盟骨关节炎倡议 (n = 600) 内的基金会的数据进行了分析。根据 MRI 骨关节炎膝关节评分 (MOAKS) 系统 (0-3) 测量 15 个膝关节分区的 BML。评估的血清和尿液生化标志物如下：血清I型胶原C端交联端肽（CTX-I）、血清I型胶原交联N端肽（NTX-I）、尿CTX-Iα和CTX-Iβ，尿 NTX-I、尿 II 型胶原 C 端交联端肽 (CTX-II)、血清基质金属蛋白酶 (MMP) 降解的 I、II 和 III 型胶原（C1M、C2M、C3M）、血清高灵敏度IIb 型胶原蛋白前肽 (hsPRO-C2) 和基质金属蛋白酶生成的 C 反应蛋白新表位 (CRPM)。使用针对协变量调整的回归模型检查了 12 个月内生化标志物变化与 24 个月内 BML 之间的关联。检查了基线和超过 24 个月的 C1M、C2M、C3M、hsPRO-C2 和 CRPM 与 BML 之间的关系。12 个月内血清 CTX-I 和尿液 CTX-Iβ 的增加与 24 个月时受任何 BML 影响的亚区域数量变化的可能性增加相关。hsPRO-C2 的增加与 24 个月内受任何 BML 影响的次区域数量恶化的可能性降低相关。C1M 和 C3M 与基线时受影响的 BML 相关。血清 CTX-I、hsPRO-C2 和尿液 CTX-Iβ 的短期变化有可能作为 MRI 上 BML 进展的预后指标。C1M 和 C3M 与 MRI 基线 BML 的关联值得进一步研究。