A series of dual ligands acting on the α2δ-1 subunit of voltage-gated calcium channels and the μ-opioid receptor (MOR) was designed by merging of the two non-structurally related target pharmacophores. The new amino-acidic derivatives are represented by compound 31 (WLB-83038) which exhibits a good drug-like profile and analgesia in several pain models.

中文翻译：

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走向多靶点配体作为疼痛治疗：电压门控钙通道的 Cavα2δ-1 亚基和 μ-阿片受体的双配体

通过合并两个非结构相关的目标药效团，设计了一系列作用于电压门控钙通道的α2δ-1亚基和μ阿片受体（MOR）的双配体。新的氨基酸衍生物以化合物31 (WLB-83038) 为代表，在多种疼痛模型中表现出良好的药物样特征和镇痛作用。